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Yala sugunɛ sɛgɛsɛgɛli nɔgɔman bɛ se ka Alzheimer bana daminɛ na, ka sira dabɔ jamanadenw ka sɛgɛsɛgɛli porogaramuw kama wa? Frontiers in Aging Neuroscience ka sɛgɛsɛgɛli kura b’o jira tiɲɛ na. Ɲininikɛlaw ye Alzheimer banabagatɔ kuluba dɔ sɛgɛsɛgɛ, u juguya tɛ kelen ye ani mɔgɔ kɛnɛmanw, minnu hakili tun bɛ cogo la walasa ka danfara dɔn sugunɛ biyomarkɛriw la.
U y’a ye ko asidi formiki min bɛ sugunɛ na, o ye hakililata dɔgɔyali taamasiɲɛ ye min bɛ mɔgɔ hakili la, wa a bɛ se ka kɛ Alzheimer bana daminɛ na. Fɛɛrɛ minnu bɛ yen walasa ka Alzheimer bana sɛgɛsɛgɛ, olu sɔngɔ ka gɛlɛn, u man nɔgɔn, wa u tɛ se ka kɛ ni sɛgɛsɛgɛli kɛcogo kɔrɔ ye. O kɔrɔ ye ko banabagatɔ fanba bɛ sɔrɔ dɔrɔn ni a tɛmɛna furakɛli nafama na. Nka, sugunɛ sɛgɛsɛgɛli min tɛ kɛ ni fɛn ye, min sɔngɔ man gɛlɛn, ani min ka nɔgɔn asidi foromiki la, o bɛ se ka kɛ dɔgɔtɔrɔw bɛ min ɲini tigitigi walasa ka a sɛgɛsɛgɛ joona.
Sɛbɛnnikɛlaw y’a fɔ ko: “Alzheimer bana ye bana basigilen ye min bɛ to senna ani min bɛ kɛ ni kɔnɔnafili ye, o kɔrɔ ye ko a bɛ se ka sɔrɔ ani ka to sen na san caman kɔnɔ sani hakiliɲagami jɛlen ka bɔ kɛnɛ kan.” "Bana in daminɛ bɛ kɛ ka kɔn hakiliɲagami daminɛ ɲɛ, min tɛ se ka segin kɔ, o ye sanu finɛtiri ye min bɛ se ka kɛ sababu ye ka dɛmɛ don a la ani ka furakɛli kɛ. O la, sɛgɛsɛgɛliba kɛli Alzheimer bana daminɛ na mɔgɔkɔrɔbaw la, o ka kan ka kɛ."
O la, ni furakɛli joona nafa ka bon, mun na an tɛ sɛgɛsɛgɛli porogaramuw kɛ tuma bɛɛ Alzheimer bana daminɛ na? Gɛlɛya bɛ sɔrɔ sɛgɛsɛgɛli fɛɛrɛ minnu na dɔgɔtɔrɔw bɛ baara kɛ ni minnu ye sisan. Olu dɔw ye positron emission tomography ye kunsɛmɛ na, o min sɔngɔ ka gɛlɛn, wa a bɛ banabagatɔw bila fiɲɛ fɛ. Biyomarkɛri sɛgɛsɛgɛliw fana bɛ yen minnu bɛ se ka Alzheimer bana dɔn, nka u bɛ joli bɔli walima kɔkolo tigɛcogo de wajibiya walasa ka kunsɛmɛji sɔrɔ, banabagatɔw bɛ se ka o bila kɔfɛ.
Nka, sugunɛ sɛgɛsɛgɛli tɛ mɔgɔ minɛ, wa a ka nɔgɔn, o de b’a to u ka ɲi kosɛbɛ jamanadenw ka sɛgɛsɛgɛli la. Hali ni ɲininikɛlaw ye sugunɛ biyomarkɛriw dɔn ka tɛmɛ Alzheimer bana kan, u si ma bɛn bana in daminɛcogo dɔnni ma, o kɔrɔ ye ko sanu finɛtiri furakɛli joona kama, o bɛ to ka sɔrɔ.
Ɲininikɛlaw minnu bɛ nin ɲinini kura in kɔfɛ, olu ye fɛnɲɛnamafagalan dɔ sɛgɛsɛgɛ ka tɛmɛ, n’o bɛ wele ko foromadehidi, n’o ye sugunɛ biyomarkɛri ye Alzheimer bana na. Nka, yɔrɔ bɛ yen ka ɲɛtaa sɔrɔ banaw dɔnni joona la. Nin ɲinini laban in na, u y’u sinsin foromati kan, n’o ye foromadeyidi fɛnɲɛnamafagalan ye, walasa k’a dɔn n’a bɛ baara kɛ ka ɲɛ i n’a fɔ biyomarkɛri.
Mɔgɔ 574 de ye u sen don o sɛgɛsɛgɛli la, wa a senfɛmɔgɔw tun ye ŋaniyajirabaga kɛnɛmanw ye minnu hakili la, walima bana taabolo tun tɛ kelen ye, k’a ta hakili dɔgɔyali la u yɛrɛ la ka se bana dafalen ma. Ɲininikɛlaw ye sugunɛ ni joli sɛgɛsɛgɛli kɛ ka bɔ lajɛdenw na, ka hakili ta fan fɛ sɛgɛsɛgɛli kɛ.
Nin ɲinini in y’a jira ko asidi foromiki hakɛ min bɛ sugunɛ na, o cayara kosɛbɛ Alzheimer bana kulu bɛɛ la, wa a ni hakili dɔgɔyali bɛ tali kɛ ɲɔgɔn na ni a bɛ tali kɛ mɔgɔ kɛnɛmanw na, hakililata dɔgɔyali kulu fɔlɔ fana sen bɛ o la. O b’a jira ko asidi foromiki bɛ se ka kɛ biyomarkɛri ye min bɛ se ka kɛ sababu ye ka Alzheimer bana daminɛ na.
A nafa ka bon kosɛbɛ, tuma min na ɲininikɛlaw ye sugunɛ foromate hakɛ sɛgɛsɛgɛ ka fara Alzheimer joli biyomarkɛriw kan, u y’a ye k’u bɛ se ka banabagatɔ ka bana taabolo fɔ ka ɲɛ. Nka, ɲinini wɛrɛw ka kan ka kɛ walasa ka jɛɲɔgɔnya min bɛ Alzheimer bana ni asidi foromiki cɛ, o faamuya.
Sɛbɛnnikɛlaw ko: “Asidi formiki sugunɛ y’a jira ko a bɛ se ka kɛ sababu ye ka Alzheimer bana sɛgɛsɛgɛ joona.” “Sugunɛ biyomarkɛri sɛgɛsɛgɛli min bɛ kɛ Alzheimer bana na, o ka nɔgɔn, wa a musaka ka dɔgɔ, wa a ka kan ka don mɔgɔkɔrɔbaw ka kɛnɛya sɛgɛsɛgɛli kɛcogo kɔrɔw la.”
Wang, Y. ani a ɲɔgɔnnaw. (2022) Sugunɛ asidi foromiki seginnkanni sigida la, n’o ye biyomarkɛri kura ye min bɛ se ka kɛ Alzheimer bana na. Dan minnu bɛ kɔrɔya ka hakili-la-ko la. doi.org/10.3389/fnagi.2022.1046066. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.
Tags: kɔrɔya, Alzheimer bana, biyomarkɛriw, joli, kunsɛmɛ, bana basigilenw, bana basigilenw, fɛnɲɛnamafagalanw, hakiliɲagami, banaw sɛgɛsɛgɛli, dɔgɔtɔrɔw, foromadeyi, hakiliɲagami, positron emission tomography, ɲinini, tomography, sugunɛ sɛgɛsɛgɛli
Pittcon 2023 la, Filadɛlifi, Pennsylvanie, an ye ɲininkali kɛ Karamɔgɔ Joseph Wang fɛ, n’o ye ɲinan Ralph N. Adams ka laadalata sɔrɔ, n’o ye Analytical Chemistry ye, biyosensɛri fɛɛrɛbɔcogo caman kan.
Nin ɲininkali in kɔnɔ, an bɛ kuma ninakili biyɔpisi kan ani a bɛ se ka kɛ baarakɛminɛn nafama ye cogo min na walasa ka biyomarkɛriw kalan banaw dɔnni joona kama ni Mariana Leal ye, min ye Owlstone Medical ka jɛkulu ɲɛmɔgɔ ye.
An ka SLAS US 2023 seginnkanni hukumu kɔnɔ, an bɛ baro kɛ siniɲɛsigi laboratuwari kan ani a bɛ se ka kɛ cogo min na ni Luigi Da Via ye, GSK Test Development Team Lead.
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